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Interestingly the role ofCNVs was also associated with an aggressive phenotype in the offspring, whereCNVs from one parent were commonly inherited with a germline TP53 mutationfrom the other parent [ 65]. Walker KK, Levine AJ (1996) Identication of a novel p53 functional domain that is neces -sary for efcient growth suppression.
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The thinning of the wall of thevillus is caused in part by surface and volume expansion ofthe villi, as well as by the degeneration of the inner cytotro-phoblast layer (see Fig.